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Omega-3 Benefits

Omega-3 fatty acids benefit the hearts of healthy people as well as those who have cardiovascular disease.

In 2002, the American Heart Association (AHA) released a statement on the effects of Omega-3 fatty acids on heart function (including antiarrhythmic effects), hemodynamics (cardiac mechanics) and arterial endothelial function.

Large-scale epidemiologic studies suggest that people at risk for coronary heart disease benefit from consuming Omega-3 fatty acids. Particularly those from fatty fish like trout, mackerel, tuna and salmon help:

  • Decrease risk of arrhythmias, which can lead to sudden cardiac death
  • Decrease triglyceride levels
  • Decrease growth rate of atherosclerotic plaque
  • Lower blood pressure (slightly)

What Your Patients Need to Know…

All Fish Oil Supplements are NOT the Same

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AHA logoAccording to the American Heart Association:

“Taking EPA+DHA ranging from 0.5 to 1.8 grams per day (either as fatty fish or supplements) significantly reduces deaths from heart disease and all causes.”


“Clinical trials have shown that Omega-3 fatty acid supplements can reduce cardiovascular events (death, non-fatal heart attacks, non-fatal strokes).”


“Coronary artery disease patients may not be able to get enough Omega-3 by diet alone. These people may want to talk to their doctor about taking a supplement.


“Supplements also could help people with high triglycerides, who need even larger doses.”

Article at www.americanheart.org
Publication at circ.ahajournals.org

Besides AHA, regulatory bodies FDA and USDA have also made official recommendations for daily Omega-3 consumption.

ACC logoAccording to American College of Cardiology Foundation’s Expert Consensus Document:

“Omega-3 fatty acids reduce cardiovascular events, sudden death, and overall mortality.”


“Omega-3 fatty acids may also affect CHD outcomes by decreasing triglyceride levels, ventricular arrhythmias, decreasing fibrinogen levels and platelet counts, modestly reducing blood pressures, and decreasing cell proliferation.”


“Omega-3 fatty acids have been tested in several secondary prevention trials. The GISSI-Prevenzione study is the largest of the controlled trials investigating omega-3 fatty acid supplements (1 g per day) and CHD risk. In this trial, total mortality was reduced by 20% and sudden death by 45%”

Source: Vogel, JH. et al. J. Am. Coll CardioL. 2005 July 5; 46(1): 184 – 221.

Article at www.acc.org.

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{ 43 comments… read them below or add one }

Jerzy Chachaj, MD December 7, 2012 at 3:07 am

Highly recommended !

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Dr. N. Shaikh March 8, 2013 at 10:51 pm

Looks like a good product specially price vs amounts of Omega-3 content. Two questions
1. In your 1200 mg pill, you claim to have close to 820 mg of EPA. How much DHA and other Omega-3s?. What is the ratio of EPA to DHA?
2. Have you done any clinical trials on your product to support your claims?

Thanks,

Nisar

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Vin Kutty March 10, 2013 at 11:53 pm

Hi Dr. Shaikh – It is a 1300 mg pill, with 780 mg of EPA, 260 mg of DHA – this gives you a 3:1 ratio. We are in the middle of a couple of clinical trials, one on metabolic markers and another on mood.

– Vin Kutty

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Inder April 14, 2013 at 2:59 am

Hi,

What fish do you use to extract the fish oil…and what is the mercury levels in your tablets?

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Vin Kutty April 14, 2013 at 11:26 pm

Hi Inder – we use Alaskan Pollock and Whiting. The mercury levels were less than 0.01 parts per million or 10-times less that the allowed limits. See more here: http://www.ifosprogram.com/files/IFOS%20Innovix%20OmegaVia%20Batch%20S2A042.pdf

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Jose C. Tutor, MD, PharmD, PhD April 18, 2013 at 4:49 pm

In my view the EPA/DHA ratio in Omegavia is optimal for treatment of inflammatory processes. I will test immediately this omega-3 preparation.
Usually fish oil concentrates are administered once or twice daily with food. However, Svein Torgersbraten in his recent book “Omega-3 and Vitamin D Secrets” suggest to  make an emulsion of cod liver oil with whole milk, and take it on an empty stomach at least from 4 hours before to achieve higher levels of omega 3 in blood and tissues.
Have you done any study on the bioavailability of omega-3 using different protocols of administration?
Thank you very much for your attention

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Vin Kutty April 18, 2013 at 6:10 pm

Hi Dr. Tutor – the high-EPA formula in OmegaVia was specifically designed to address inflammation. More here: http://www.omegavia.com/why-omegavia-is-high-in-epa-omega-3-part-1/

Cod liver oil (old technology) and pharma grade fish oil of today are very different delivery forms. Mixing Cod Liver Oil (which is a low-potency triglyceride form oil) with milk is very different than taking OmegaVia, which is a very high potency ethyl ester form oil. Triglyceride form oils can be taken on an empty stomach or with foods. Ethyl ester form oils are best absorbed when taken with foods. The adjoining fats present in meals helps bioavailability. Ethyl ester form of Omega-3 are not very well absorbed on an empty stomach. This is fairly established science, so we have not repeated any of these studies. However, we are in the process of a doing a couple of clinical trials with OmegaVia on depression and lipid-management.

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Betty Babineaux June 17, 2013 at 5:04 pm

Triple strenght fish oil of 1400 omeaga3 900 is that good for constipation iam taking 3 a day

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Vin Kutty June 22, 2013 at 3:56 am

Hi Betty – there is not much evidence to show that fish oil will help constipation. I suggest, vegetables, more water, probiotics, exercise etc.

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Asmizan October 19, 2013 at 11:17 am

Hi Vin,

If i take regular fish oil with 70% fish fat, will that amount of fish fat can cause me any health problem? Weight gain, for example.

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Vin Kutty October 19, 2013 at 6:52 pm

Hi Asmizan – no it wont cause health problems but you may not see the benefits of Omega-3 with low potency fish oil.

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William November 7, 2013 at 8:44 am

Hi, Vin:

Does Omegavia contains protein ?

Thank you.

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Vin Kutty November 8, 2013 at 12:29 am

Hi William – the oil in OmegaVia does not contain protein, but the gelatin capsule shell is protein. So, yes, it contains protein.

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William November 17, 2013 at 2:18 pm

Hi, Vin:

Thank you for your reply.

Can i know how much protein is contained in 1 softgel ?
My wife is suffered from knee cap problems and doctor advice is tentatively cut off intake of protein.

Thank you for your advice.

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Vin Kutty November 17, 2013 at 6:51 pm

Hi William – there is roughly a third of a gram of protein per capsule. On a separate note, I strongly urge you to seek another doctor. At least get a second opinion.

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Gayla M December 31, 2013 at 8:26 pm

What about radiation in the fish? There is concern that Alaska’s fish are now contaminated with radiation from Japan.

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Vin Kutty December 31, 2013 at 10:16 pm

Hi Gayla – I share your concern.

We are keeping an eye on the developing situation in the Pacific. Sadly, it is not an inconsequential development. So your concern is appropriate.

We have three sources of radiation data:
Scientific publications – http://www.pnas.org/content/early/2013/05/30/1221834110
GOED, Global Organization for EPA and DHA.
Fishery data from our supplier

Based on the above, it is fair to state that fish from the Pacific have elevated Polonium and Cesium levels. But to put things in perspective, a Tuna fish from the Pacific would have only 5% of the radiation found naturally in a banana. See reference above. If you eat a pound of Pacific Tuna every day, you would still have less than 20% of the radiation that you get from flying from New York to LA.

I’m not trying to say that there is less risk than before. Sadly, our post-Fukushima reality is that all oceans, not just the Pacific is slightly more contaminated. And 95%+ of all fish caught for fish oil supplement use is caught in the Pacific. We will not use Chinese fish oil caught in the Indian and Atlantic oceans due to other even more severe quality issues.

I personally take 4 OmegaVia capsules per day and give it to my family. So for your health and mine, we will be monitoring this situation and doing everything we possibly can to do the right thing.

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Eric January 6, 2014 at 10:37 pm

Vin..

Seems like an amazing product and a serious alternative to Vascepa…
Im currently taking 2-3 gelcaps 2X daily Puritans Pride Triple Strength Omega 3 @ 1360 MG (Link Here http://www.puritan.com/puritans-pride-brand-0102/triple-strength-omega-3-fish-oil-1360-mg-016105?scid=28176) which yields EPA @ 625mg || DHA@244mg per GEL CAP so total dosage @ 1875 EPA and 738 DHA twice daily..

Is Puritan a quality product/option….Is this overkill/not adequate..

Compared to Omegavia is this selling my self short?

Youre commentary is appreciated

Thank you

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Vin Kutty January 7, 2014 at 1:30 am

Hi Eric – Puritans Pride is a good brand. It is owned and operated by the folks at US Nutrition and Natures Bounty, the largest value brand and private label supplement company in the US. So they know what they’re doing.

But how much Omega-3 you need depends on your diet and your health goals. You are taking 5,226 mg of Omega-3 per day. That’s more than I would take. I prefer to see that number at 4,000 or less. Also, are you seeing the results you’re looking for? If you’re after triglyceride reduction, most OmegaVia customers take 3 or 4 pills per day. You may want to read this if you are taking it for triglyceride reduction: http://www.omegavia.com/why-pharmaceutical-grade-fish-oil-is-better/ FYI – your product is 64% Omega-3 potency. According to the study cited in the link above, Omega-3 at 63% or so did not lower TG significantly. TG reduction is more dramatic once you get to 80-85% potency.

If you’re taking it for joint health or mood etc., you approach may need to take a higher EPA product and less of it.

If you’re healthy and taking it for general health, then it is definitely overdosing.

Overall, I don’t think you’re selling yourself short, but I also don’t know your diet, health goals and budget. Are you OK with no enteric coating, are you OK with soy? There are several questions to ask yourself before you find the right product for you. In the meantime, I am happy answer questions to help you choose the right product, be it OmegaVia or not.

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ANNA STEIN March 12, 2014 at 10:19 pm

Hello,
My local store has a Omega-3 product that yields these contents:
http://www.doctorsnutrition.com/store/pc/viewPrd.asp?idproduct=575&idcategory=39

Serving Size: 2 Softgels
Servings Per Container: 30

——————————————————————————–
Amount Per Serving: % Daily Value

——————————————————————————–
Calories: 25 Calories From Fat: 25

——————————————————————————–
Total Fat: 2.5 g. 4%
Cholesterol: 25 mg. 8%

——————————————————————————–
Vitamin D3 ( cholecalciferol): 1,000 IU. 250%
Marine Lipid Concentrate: 2,500 mg. *
yielding EPA: 900 mg.
DHA: 660 mg.

Should I be concerned of the cholesterol?
Does this mean their product has higher Omega-3 than OmegaVia?
Thanks, Anna

Reply

Vin Kutty March 12, 2014 at 10:59 pm

Hi Anna – this Doctors Nutrition product has 750 mg of Omega-3 per pill. Notice that the serving size is 2 softgels – that’s easy to overlook, but it means that you have to divide all numbers by two. So it becomes complicated. So this item has 750 mg Omega-3 while OmegaVia has 1105 mg of Omega-3 per pill. There is usually little or no cholesterol in highly purified fish oils, so I’m not sure why this one has more than usual…

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GB May 22, 2014 at 2:51 pm

Would you recommend fish oil in patient with chronic gout symptoms. Is your fish oil distilled of purines?

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Vin Kutty May 22, 2014 at 5:58 pm

Hi GB – I would check with your doctor before adding or removing anything from your diet. Having said that, there are no purines in OmegaVia. Fish oil is not a concern for gout – fructose from juice, sodas, sweets is the real culprit.

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Rinna August 24, 2014 at 5:27 pm

Hello Sir,
I was wondering if you now have the FISH OIL for kids, you said would be available by 2013? I need a really good one to replace what I have been using for my 7 year old son with ADHD. Thanks.

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Vin Kutty, MS August 24, 2014 at 10:56 pm

Hi Rinna – try this product: http://www.omegavia.com/epa-500/ this pill is about half the size of our regular OmegaVia. Your 7-year-old may be able to swallow it…??

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Millard Griffin September 14, 2014 at 5:57 pm

How can I find about omegavia and drug interactions? I take Crestor 40 mg daily, diazide 37.5/25 daily, Aggrenox 25/200 twice daily, Prilosec 40 mg daily, Valium 2mg twice daily and Lotrel 5/10 daily. Is there any adverse interactions when taken with above drugs. I also take glucosamine chondroitin twice daily.
Thanks, Millard

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Vin Kutty, MS September 14, 2014 at 7:02 pm

Hi Millard – OmegaVia (and other pharmaceutical grade fish oils) do not interfere with prescription drugs. Some doctors prefer to have their patients go off OmegaVia prior to elective surgery. Otherwise, there are no contraindications. Since you’re taking so many prescriptions, I strongly advise you check with your doctor before you make any changes to your routine.

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Anne September 25, 2014 at 3:02 pm

Very informative website!

Should we have concern over lipid peroxidation with high dosages – like 6gm/day of Omega 3’s? http://www.hindawi.com/journals/bmri/2013/464921/
http://www.ncbi.nlm.nih.gov/pubmed/12568661

A colleague wants to recommend 6gm/day of Omega 3’s to his chronically ill patients with inflammation.

Many thanks

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Vin Kutty, MS September 25, 2014 at 11:14 pm

Hi Anne – short answer: yes. But if you’re even remotely interested in health, you should never settle for short answers. :-) The more nuanced answer is that you CAN give someone 6 or 10 grams of Omega-3 per day if the goal is to quickly reduce inflammation, especially if taken with a baby aspirin. But I would limit this to a few days or a few weeks at the most. You should know if such a high dose of Omegas plus aspirin is making a difference. If you notice inflammation drop, then you have your answer, which is that inflammation is a problem. Continuing to take huge doses of Omega-3 is not the answer but to get to the root cause of the inflammation, which is usually what’s at the tip of the fork or straw. Of course, gut health and lifestyle issues also contribute to inflammation so that will have to be addressed as well. At that point, I’d drop to 2 or 3 grams of Omega-3 per day and maintain a low-sugar and low-Omega-6 diet.

Staying at 6 grams per day permanently is not only not addressing the issue but venturing into territories of PUFA consumption that’s new to humanity. Of course with seed oils contributing so heavily to our caloric intake, I’d say we need to start with Omega-6 reduction rather than bumping up Omega-3.

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Anne September 26, 2014 at 1:27 pm

Thank you for your prompt, considered response Vin.

We know what the inflammation is from, but treating these patients will take a year plus. I appreciate your concerns re getting to the root cause. And I appreciate the concept of lessening n-6 oils.

I was concerned re lipid peroxidation of these highly unstable oils. So is the author of this study http://dx.doi.org/10.1155/2013/464921 and the other studies cited.

Does OmegaVia check their oils for lipid peroxides? With 6 grams of n-3 oils/day, is a mixed tocopherol Vit E warranted in addition?

thank you very much–

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Vin Kutty, MS September 26, 2014 at 5:33 pm

Hi Anne – lipid peroxidation is always a concern with Omega-3 and 6 fats. This is why I get concerned when I see a ‘more is better’ approach to fish oil. There is probably a U-shaped benefit curve. I imagine that the U-curve shifts left or right based on level of inflammation and/or Omega-6 status. We’ve explored the risks associated with the inadequate consumption, but risks associated with high dosage (10 grams of Omega-3 or higher) hasn’t been fully explored. Traditional diets in Japan, Iceland and Arctic approach or exceed 10 grams per day without noticeable harm. This is often cited by researchers and marketers as a green light for ultra high doses. Listen to this very recent interview: http://www.nutraingredients.com/On-your-radar/Omega-3/UK-researcher-backs-supplements-for-omega-3-intakes

Yes, we check oils that go into OmegaVia for peroxides, acid value, anisidine – all markers of oxidation. All these factors always fall within our (and industry) specifications. All these figures are published at IFOS, third party testing: http://www.nutrasource.ca/ifos/files/ifos%20innovix%20omegavia%20batch%20ov140277.pdf

If I were taking 6 grams of Omega-3, I would take Vitamin C, alpha lipoic acid, curcumin, and a high-gamma or high-delta tocopherol. Regular Vitamin E pills are virtually useless (or may even cause harm) because they are synthetic forms of alpha. For antioxidant protection, you need gamma and delta. Alpha is a poor antioxidant…I’m not sure what it does besides give people false comfort. http://www.amazon.com/Now-Foods-Advanced-Soft-gels-120-Count/dp/B0013HV8RI/ is pretty cheap. I take a more expensive form: http://www.amazon.com/Jarrow-Formulas-Famil-E-60-Softgels/dp/B0013OSI5G/

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Laurie Moser October 18, 2014 at 7:02 pm

Hi Vin,
Both the Now Foods and Jarrow Gamma-e supplements contain soy, which I avoid (and I thought you did, too). I finally found a Gamma-e product without soy, and the gamma/delta/beta levels are quite a bit higher than the Jarrow, as well. Is there a reason you prefer the Jarrow? I’ve always had terrific health improvements in the past when sticking with your recommendations, so I value your opinion.

Thanks so much!

Anne September 26, 2014 at 1:33 pm

Hello Vin,

I am confused when I read different articles about n-3 oils. I see nationally recognized MD specialist such as Perlmutter (neurology) and Sinatra (cardiology) recommending DHA over EPA for neuro and cardiac benefits.

Are these docs, behind the learning curve on n-3’s?

My take home from your blog (and reading Dr. Barry Sears) (both you selling high EPA oils) is that EPA is where it’s at for health benefits unless pregnant, nursing, a child or recovering from brain trauma, stroke.

Is the research just not conclusive yet re EPA vs DHA particular health benefits?

Thank you for your generous sharing of your knowledge.

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Vin Kutty, MS September 26, 2014 at 5:44 pm

Hi Anne – I love your questions. Keep em coming.

DHA is absolutely essential. We need SMALL quantities of it regularly. It is stored for very long periods of time since it is a STRUCTURAL fatty acid – it becomes a part of your body and it stays put, often for years. More here: http://www.omegavia.com/why-omegavia-is-high-in-epa-omega-3-dha-and-your-brain/

Perlmutter, Sinatra and Oz are specialists in their own fields. Their hearts are in the right place, but to use your words, they are ‘behind the learning curve.’ I’d challenge all three of them to a civil debate.

Barry Sears knows a HECKUVA lot more about Omega-3 than I do. But we both sell high-EPA oils, so that makes our arguments suspect regardless of the veracity of our claims. I can live with that…but know that we will be introducing a DHA-only product in 2015 for mommies and others concerned about DHA. The DHA vs EPA debate is far from over, but so far, EPA appears to help with depression and DHA or EPA + DHA seems to help with hypertension. For the rest of us, taking both but with a slight excess of EPA is probably prudent.

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Anne September 27, 2014 at 2:57 am

Thank you very much Vin . Not sure if you have seen this 2012 article by Sears, “What are the real differences between EPA and DHA”, http://www.psychologytoday.com/blog/in-the-zone/201204/what-are-the-real-differences-between-epa-and-dha

It does seem like you two are on the same page with re to EPA, DHA.

thanks again for you help !

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Vin Kutty, MS September 27, 2014 at 5:44 pm

Hi Anne – yes, I’ve read that article. Very pertinent for the Psychology Today crowd.

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Anne October 19, 2014 at 4:18 pm

Hi Vin,
My understanding was that the gamma portion was desirable as it was particularly good for inflammation,,,, yay? nay?
Laurie, what’s the name of the product you are referring to?

thanks,

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Vin Kutty, MS October 20, 2014 at 2:54 am

Hi Anne – biological activity of gamma and delta are not as established as it is with alpha. Yes, gamma helps with inflammation. Delta is best as antioxidant, followed by gamma. So their roles in our health is all still being figured out. For now, my advice would be to get it from foods as much as possible. I suggest not going for isolated nutrients. Take a combo of all eight E forms if you must supplement.

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AJ October 29, 2014 at 5:21 am

Hi Vin

My wife is 15 weeks pregnant and currently takes a prenatal vitamin with 200 Mg DHA- I am seeing info that unto 800 mg is recommended- whats your take and what brand would you suggest

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Vin Kutty, MS November 3, 2014 at 7:49 pm

Hi AJ – yes, I believe she will need more than 200 mg DHA. Frankly, she will need more than just DHA. More here: http://www.omegavia.com/fish-oil-during-pregnancy/ I suggest brands and dosage in the link.

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Vin Kutty, MS October 19, 2014 at 4:11 pm

Hi Laurie – long time! First of all, kudos for realizing that ‘Vitamin E’ is more than just one ingredient. It’s about 8 different forms – 4 tocopherols and 4 tocotrieneols. The stuff you get at the local Costco or drug store is a synthetic version of one of those 8 forms…and it’s barely absorbed and may cause more harm than good. So your trying a Gamma-E formula is a good start. I suggest you go for a formula that contains the tocotrieneols as well. Something like Jarrow’s Famil-E. It has all 8 forms. The issue I have with some Gamme E formulas (besides lacking tocotrieneols) is that since they use soy tocopherols, they are high in gamma-tocopherol. I’d rather find a sunflower derived tocopherol mix that’s higher in alpha-tocopherol. Soy tocopherols is about 70% gamma. Sunflower tocopherol is about 90% alpha, which is better absorbed. I’d prefer to avoid soy if I can, but I’m not terribly bothered by extracts from soy like tocopherols since there are no soy allergens present. Taking a soy tocopherol formula with all 4 tocopherols is far better than taking a synthetic version of alpha. I take the Famil-E product, but you may want to call around and ask if your product uses soy or sunflower. Companies will use soy because it is cheaper than sunflower tocopherol.

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Laurie Moser October 20, 2014 at 5:39 am

Vin, I should have known you had already identified the best Vitamin E supplement. After a closer look at the one soy-free gamma-e product, I realized that it contained NO tocotrieneols at all.

(For Anne, the product was Swanson Ultra Maximum-Strength Tocopherol.

I thought surely my high-fat Paleo diet was providing enough Vitamin E, but recent functional lab work revealed I need more antioxidants. So I’m glad I found this thread. Thanks again!

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Vin Kutty, MS October 20, 2014 at 5:00 pm

Hi Laurie – if you eat a variety of nuts and seeds and eggs as a part of a paleo diet, you probably are getting enough Vit E. You may benefit from including colorful berries and leafy veggies as well.

Not sure if you knew that high intake of synthetic alpha tocopherol (virtually all Vit E in stores) by itself can wipe out some of your important gamma tocopherol. Makes you wonder about the validity of all the ‘Vitamin E doesn’t work’ studies that used synthetic alpha to come to those conclusions. Many of those were huge, expensive studies and as a result of the negative headlines, many people have walked away from Vitamin E…or are downright scared of it. As far as the source of scientific research funding, the case is closed. I doubt anyone is repeating those ‘negative’ studies with a full spectrum of Vit E in natural ratios.

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