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Krill Oil vs Fish Oil: New Scientific Evidence

by Vin Kutty on December 3, 2010

krill oil vs fish oil
In a previous blog, I discussed the cost and benefits of Krill oil vs Fish Oil.

The message was: Krill oil is definitely better than fish oil, but only a little bit.

An unpublished study presented by Neptune Krill Oil (NKO) in 2009 showed that Krill oil was about 30 to 40% better at getting Omega-3 incorporated into your body.

A New Clinical Study: Same Results

Krill oil vs Fish Oil - new scientific evidence
Now, a new study was just published by Aker BioMarine, the makers of Superba krill oil. The study titled Metabolic Effects of Krill Oil are Essentially Similar to Those of Fish Oil but at Lower Dose of EPA and DHA, in Healthy Volunteers was published in the Nov. 2010 issue of Lipids Journal.

See first page of study here.

In this paper, we once again, get confirmation that krill oil is better than fish oil. But again, only by a little bit.

Here is the result in a nutshell:

The health benefits of 1000 mg of fish oil Omega-3 can be had with about 650 mg of Krill oil Omega-3.

In other words, Krill oil is 1.5X better than Fish Oil.

Practical Example: MegaRed Krill Oil has 90 mg of Omega-3 from Superba Krill Oil. Based on this new research, you will need 7 to 8 MegaRed pills to equal 1000 mg of Omega-3 from fish oil.
krill oil vs fish oil

At $0.49 per pill, that’s $3.92 per day (Walgreens price).

Patients in this study took the equivalent of 7 MegaRed pills a day, and yet, there was no reduction in triglycerides or cholesterol.

MegaRed packaging and marketing materials suggest a dosage of just one small pill per day.

Krill Oil vs Fish Oil: Study Conclusions

  1. There is no difference in how much Omega-3 is absorbed into your body
  2. No difference in the reduction of cholesterol
  3. No difference in the reduction of triglycerides
  4. No difference between HDL cholesterol
  5. No difference in markers of oxidative stress (F2-isoprostane)
  6. No difference in markers of inflammation (C-reactive protein)

Krill Oil’s Little Surprise!

For the most part, this paper says that krill oil is better than fish oil.

But there was a nasty little surprise hidden in there!

Unlike fish oil, Krill oil increases the level of Arachidonic acid (AA) in your body.


AA is a nasty little Omega-6 that causes a lot of health problems if its levels are too high.

Dr. Barry Sears calls AA “possibly the most dangerous fat known. If you inject AA into rabbits, they will die within 3 minutes.”

Your body needs tiny little amounts of AA, but get a little more than you need…and you have the perfect ingredient to create pain and inflammation.

Got arthritis? AA will make it worse.


Got gum disease? AA will make it worse.

If you’re perfectly healthy, a little bit of AA won’t hurt you, but if you have any inflammatory disease, even a little extra AA will make your life miserable.

Bottom-line – Krill oil vs Fish oil:

Based on this study (read the study here),

  • Krill oil is still better than fish oil.
  • Krill oil is 1.5X times better than fish oil.
  • Krill oil increases pain-causing Arachidonic Acid
  • There is no difference between Krill oil and Fish oil when it comes to blood lipids like cholesterol, triglycerides, etc.

But Krill oil is 10X more expensive than fish oil (on an Omega-3 basis.)

Why consumers continue to buy and pay 10X more for a product that provides only 1.5X more benefit will continue to astound me.

The authors of the study did not do this, but I suspect that if they had compared Krill oil vs Fish Oil in EHTYL ESTER form, Krill may have performed even better. Possibly 2X better? But still, in my opinion, 2X better does not justify a 10X premium in price.

Zucker Diabetic Fatty

No, that’s not an insult.

It’s a kind of an obese rat used in clinical research.

An unpublished report from the good folks at Neptune compares their krill oil with Lovaza in rats. They found that their new pharmaceutical grade krill oil called CaPre reduced LDL (bad) cholesterol significantly in rats while Lovaza (prescription fish oil) did not. They also noticed a significant reduction in triglycerides with their krill oil.

Of course, this preclinical study was performed on rats. It looks good for their future clinical studies on humans.

And finally…

krill oil vs fish oil

“Thou shalt not piggyback flax on omega-3 DHA and EPA fish oil science. Same to you, krill.”

- Todd Runestad, The 10 Commandments of Ingredient Sourcing, in Functional Ingredients magazine.

krill oil vs fish oil

So the last word on Krill oil is far from written.

DISCLAIMER: The contents of this blog do not constitute medical advice. This is merely an open discussion of the science behind health and nutrition. Please consult your physician for medical advice.

 Author Vin Kutty is an expert on krill oils and fish oils About the Author: Vin Kutty is OmegaVia’s Scientific Advisor and Chief Blogger. He is a nutritionist, author, and Omega-3 expert with over 20 years of experience. Email him.

Krill oil vs Fish Oil Supplements

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{ 9 comments… read them below or add one }

daniel deck August 17, 2011 at 9:48 pm

I have used Krill oil and its much better than fish oil. The krill is a small shrimp-like marine crustacean. There are 85 types of krill present in the world’s ocean, the most abundant is the Antarctic Krill (Euphasia Superba). Krill oil Professional, this unique product is formulated using only Krill Oil that has earned Consumer Lab Quality Seal of Approval for purity, potency and freshness.


John March 24, 2012 at 12:00 pm

How does krill oil increase Arachidonic acid levels more than fish oil when krill contains astixanthin and fish doesn’t? Also, How is there no difference in triglycerides between fish oil and krill oil when fish is a triglyceride and krill is a phospholipid? Something doesn’t add up here…


Omegavia March 24, 2012 at 12:35 pm

Hi John – the study is not very clear about how and why it increases Arachidonic acid (AA). It’s puzzling to me too. But to put things in perspective, the amount of Arachidonic Acid increase is very minor. Eating serving of french fries cooked with corn oil probably increases AA a lot more. Having said that, Astaxanthin has NOTHING to do with AA. AA is a by-product of the eicosanoid pathway – it comes from Omega-6 metabolism. There is no connection with astaxanthin.

The fact that the molecular structure of fish oil is often in the triglyceride form (3 fatty acids connected to a glycerol backbone) has nothing to do with the clearance of triglycerides in the blood. They are two separate issues – molecular structure versus metabolic effect.
- Vin


Eric Schmall October 29, 2012 at 3:29 am

I have found no evidence online that krill oil increases arachidonic acid. Can you supply a link? The only reason that might happen is the presence of a polyunsaturated oil in the capsule which used to be the case. There are no carrier oils in NKO at the present time. Otherwise, I’d suspect the study of being flawed. Thanks very much.


Vin Kutty October 29, 2012 at 4:37 pm

Hi Eric – here is the link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024511/ the paper is open-source and freely available.

To put things in perspective, I think the Arachidonic Acid (AA) increase is minor. You’d probably get a bigger AA spike after eating french fries or a donut cooked in Omega-6-rich soybean oil. But one of the reasons I take Omega-3 is to reduce the impact of AA on my inflammation. You need EPA to do this. Krill oil is a poor source of EPA, so I high-EPA fish oils. Regardless, the following is a quote from the study:

“The level of arachidonic acid (C20:4n-6) increased from baseline in the krill group, whereas a decrease was observed in the fish oil group. The changes in arachidonic acid between the fish oil and the krill oil groups, and the control group differed significantly (p = 0.001). Pairwise comparisons showed that the mean increase in arachidonic acid in the krill oil group was significantly different from the mean decreases in the fish oil and control groups, but there was no significant difference between the mean changes in arachidonic acid level between the fish oil and control groups.”

I don’t think the study is flawed…but both the study and I may have overstated the magnitude of this new finding. And there is usually no need for carrier oil, polyunsaturated or otherwise, in krill or fish oils.

My issue with krill oil is not the AA production, but rather the low dosage people end up consuming due to the low payload in the small capsules and the deceptive marketing that encourages it.
- Vin Kutty


Veda December 29, 2012 at 12:53 am

Why is there so little DHA in MegaRed Krill Oil. How can it be as effective as fish oil? We are told the daily intake should be 600 mg of DHA.


Vin Kutty December 29, 2012 at 1:03 am

Hi Veda – krill oil is naturally low in both EPA and DHA. It’s just the way the critter was built. Cold water fish are much better source of both EPA and DHA. Whoever told you that you must take 600 mg of DHA per day is wrong. The adult human brain can only absorb about 3 mg of DHA per day. If you include all the other organs, you’d use up about 50 mg of DHA. The 600 mg DHA per day thing is a popular myth that has no basis in science. Unless of course, you’re pregnant, in which case, 600 mg DHA isn’t enough. We have a few blogs about to be published that go into much more detail. Stay tuned.
- Vin Kutty


Ginger October 18, 2013 at 7:08 am

-Krill’s plentiful EPA and DHA has been scientifically studied to significantly reduce plasma arachidonic acid (AA).-

So who’s right ?


Vin Kutty October 18, 2013 at 5:27 pm

Hi Ginger – krill is NOT plentiful in EPA or DHA. It contain both, but only in small quantities. What krill contains a lot of is phospholipids and its benefits are independent of both Omegas. Remember that krill is better absorbed (about 1.5 times) than fish oil but again, you’re talking about a small amount of EPA and DHA. You’re better off with high potency fish oil if you’re interested in Omega-3. The math does not make sense to me.


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