Fish Oil Forms: EE vs TG – Part 2
In Part 1, we reviewed the scientific evidence of the difference in absorption between EE fish oil and its TG cousin. TG came out slightly ahead.
But…are there any problems with TG fish oil?
Let’s look at some facts:
- True TG fish oil is low in Omega-3, usually 20-30% Omega-3 or less.
- At that concentration, you’ll have to take almost a dozen pills a day to get enough Omega-3 for reducing your blood triglycerides.
- Concentrated TG fish oil (also called rTG) supplements are not exactly natural and are very expensive.
- Almost all the scientific research to date (more than 18,000 scientific papers) has been performed using EE form of fish oil and NOT the TG form.
- Prescription Omega-3 like Lovaza, Omacor, AMR-101 and Epadel are all EE forms.
Besides the increased cost and large number of pills required, there are no valid reasons to avoid TG fish oil. If you’re on a tight budget and need 4,000 mg of Omega-3 per day, rTG fish oil may cause some financial difficulty.
OmegaVia uses EE form of fish oil.
Internet and Emails as a Scare Tactic!
A lot of internet marketing and advertising chatter will have you believe that EE fish oil is pure poison! One drop and you’ll fall flat on your back. Time to meet your maker!
Not so fast, Skippy!
Moderation and common sense does not get much attention these days.
There are a lot of people (and brands) on the internet spreading fear about EE fish oil. I think this is predatory and self-serving.
SCARE TACTIC #1: Your kids will get intoxicated!
One of the points used to stir up fake-fear is alcohol.
When a molecule of EE fish oil is metabolized by your body, a molecule of alcohol is released. A teeny, tiny bit.
A daily dose of EE fish oil has about as much alcohol as a glass of orange juice. Yes, all fruits and juices have a tiny bit of alcohol in it. Nothing to worry about – your body is built for and perfectly capable of handling fruits as well as EE fish oil.
But if you believed everything you read, you’d think that little children all over the country are passing out drunk from taking a little EE fish oil!
SCARE TACTIC #2: Styrofoam Cup Parlor Trick
This is my favorite!
There is a YouTube video of someone putting ethyl ester oil in a styrofoam cup. The oil, naturally, melts through the cup. The demonstrator looks up at the camera is mock shock!
It makes for great entertainment, but the only thing it proves is what they taught me in Chemistry 101, that compounds with similar polarity attract and often dissolve each other. Unless your digestive system is composed of polystyrene, there is absolutely nothing to fear! Until then, the styrofoam cup video is a great parlor trick.
Ironically, in Asia, where they sell mostly low-potency oils, they use reverse-styrofoam-melting-trick…in other words, their advertisers are telling people that good and strong fish oils SHOULD dissolve styrofoam cups and one SHOULD ONLY BUY oils that do so.
I got this email from a customer in Malaysia, just 2 days ago:
“We see lots of demonstrations using polystyrene food box. One will cut the fish oil capsule into half letting the oil drip onto the box. Oil that ‘burns’ a hole through the box is claimed to be of the highest purity. What do you make of such claim? Is there any scientific truth there?”
These demonstrators do not understand chemistry and are hoping you’ve forgotten it since high school. If I were really cynical, I’d say they know their chemistry, but are sure you don’t!
SCARE TACTIC #3: Yikes! EE fish oil is banned in some countries!
Easy there, Skippy! Not so fast!
Japan and some EU countries distinguish over-the-counter supplements and pharma drugs. Supplements are TG fish oils. And pharmaceutical drugs are EE fish oils.
Simple rule. Keeps the kids from fighting.
Japan has had a high-EPA prescription fish oil drug in EE form for two decades. It’s sold as Epadel.
US regulations allow for EE fish oil to be sold as BOTH prescription Lovaza and OTC supplements.
Why all the scare tactics?
Profit.
And the competition is stiff.
Using fear as a selling tool is an age-old trick. Politicians do it every day! Need I say more?
Why do we use EE fish oil?
Simple. It allows for ultra-concentration of Omega-3.
TG fish oils contain 20-30% Omega-3 and cannot be concentrated.
If you want pharmaceutical grade or prescription strength fish oil, you need to concentrate the oil to 80 or 90% Omega-3. EE fish oil can be concentrated to pharmaceutical strength. TG fish oil cannot.
This concentration allows you to take fewer pills and yet get all the desired benefits of fish oil.
After all, what’s the point in taking fish oil if there isn’t enough Omega-3 in it?
Omega-3 delivered to your body in either form, EE or TG, eventually ends up in your cell membranes, where they go about doing the wonderful things they do.
EE still does the job – pancreatic lipase hydrolyses EE to a slightly less degree than TG. And at a slightly slower rate. You won’t feel the difference.
What’s rTG Fish Oil? Even more science!
Some companies now go a step further…
They start with 30% Omega-3 TG fish oil. Then convert it to 60 or 70% Omega-3 as EE fish oil. Remember, you can only concentrate fish oil in the EE form.
And then, enzymes are used to re-esterify the Omega-3 fatty acids back into the TG form. This process is called enzymatic glycerolysis. These oils are called rTG in the fish oil industry.
It’s a fancy way of getting high concentration, yet be able to say that the oil is in its ‘natural triglyceride’ form.
Is rTG Fish Oil Really ‘Natural’?
rTG is super-natural. Or nature-identical. But not natural. rTG is like those audio speakers people put in their back yards that look like rocks. Skippy tells me they are rocks.
Enzymatic glycerolysis does not produce a pure triglyceride (three glycerol molecules) product. It’s often half triglycerides and the rest of the oil is a mix of mono and di-glycerides. It’s a super-natural mix unlike what’s found in fish. Dyerberg et al. suggest this may be why it is slightly better absorbed.
Nordic Naturals uses a clever way of increasing the triglyceride content to 93%. It’s a great laboratory achievement by a pioneering company and it deserves attention and respect. But don’t confuse that with 93% Omega-3! 93% triglycerides does NOT mean it is 93% Omega-3!
Whatever the glyceride combination, rTG is perfectly fine to take and it’s very well absorbed.
This additional enzymatic step is expensive, but is it worth it?
Personally, I think it is fascinating chemistry. But it’s a lot of chemical intervention and cost for a minor benefit.
Is rTG better than TG?
Yes. A little.
A recent 2-week study by Dyerberg et al., did something, ummm…interesting, in my opinion – they indexed the results. Instead of comparing all fish oil results to placebo, they compared EE and rTG to regular fish oil. While this might seem harmless on the surface, it exaggerates the facts. It makes the difference between TG and EE APPEAR bigger.
Some call it funny math.
I’m not the only one who found this a little odd…
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“How they reported the results was instead of comparing the results to placebo, they took the position of comparing the other forms to regular fish oil and cod liver oil, “as if” regular fish oil and cod liver oil were “the standard” by which to compare the others. With this approach, the re-esterified TG concentrate form improved blood levels better than regular fish oil and cod liver oil, and the result of consuming the EE concentrate on blood levels was less than regular fish oil and cod liver oil.”
- Gretchen Vannice, MS, RD – Omega-3 Dietitian in Comments on recent studies comparing TG and EE forms of fish oil
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Like I said, funny math. Using this funny math, rTG is 70% better than EE. I’ve seen websites that claim 120-something percent better. Skippy strikes again!
Funny Math & TV CommercialsTangentially, this funny math is used to market cholesterol (statin) drugs. If people on placebo had a 1% decrease in cardiac events and people on stains had a 1.5% decrease, that HALF PERCENT difference will be conveniently interpreted as (1.5-1/1.5) = 33%. Before you know it, there is a TV ad that says statin drugs reduce your risk of cardiac events by 33%. Very clever! This has actually happened! |
The Neubronner study was longer, more robust and much more conclusive in comparing the Omega-3 Index (see Part 1) of TG vs EE.
At the end of their study, they got the participant’s Omega-3 Index up from 7 to 12.2 for the EE group and 13.2 for the TG group. That about 15% difference. Let’s be generous and say 20%. Super generous = 25%. That’s still far from the 70% that marketers of TG oils like to claim.
Regardless, if you can get your Omega-3 Index above 12, you should be jumping up and down! And EE fish oil clearly did so in this very well designed study. Nuff said.
Cost difference between EE and TG (or rTG)?
A big cost difference.
Concentrated TG oils (rTG) are very expensive.
If you buy fish oil by the truckload, like we do, there is roughly 40% premium for TG oils. That usually translates to twice the cost for you, the consumer.
There are very few well-known TG fish oil brands. Nordic Naturals Ultimate Omega and Minami Nutrition MorO-3 come to mind. Both are excellent products. I recommend them without hesitation.
They are both rTG products, which are usually about 60% Omega-3 potency. The following is a comparison of these two products with a couple of other mid-grade fish oils.


As a comparison, OmegaVia costs about as much as the GNC Triple Strength Fish Oil.
The bottom-line remains…
Are you willing to pay almost twice as much for far less than twice as much absorption?
Once you dispense with the shady marketing, you are left with two slightly different products that give you the same health benefits. Generally speaking, the strongest EE oils contain 20 to 30% more Omega-3 than the strongest TG oils. This makes the absorption claims somewhat of a wash.
Unless major new clinical evidence changes the scientific landscape, it’s a no-brainer to me.
I’m sticking with EE fish oil.
And I eat salmon frequently and avoid Omega-6-rich vegetable seed oils.
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About the Author: Vin Kutty is OmegaVia’s Scientific Advisor and Chief Blogger. He is a nutritionist, author, and Omega-3 expert with over 20 years of experience. Email him.














About the Author: Kathy Mankofsky RD, LD is a registered and licensed dietitian. She has studied Omega-3s extensively. She lives in St. Louis, Missouri.















