Fish Oil Plus Statins

The effectiveness of Combination Therapy (Statins with Fish oil) for triglyceride reduction has been widely studied. Most studies show results similar to those shown below (Chan et al, 2002)

Percent Reduction in Triglyceride Levels

Adapted from: Chan DC, Watts GF, Mori TA, Barrett PH, Beilin LJ, Redgrave TG. Factorial study of the effects of atorvastatin and fish oil on dyslipidaemia in visceral obesity, Eur J Clin Invest 2002; 32: 429 – 436.

Other Statin + Fish Oil Studies:

1. Fish Oil Boosts Statin Heart Benefits: Lancet 2007; 369: 1090–1098
2. Omega-3 Plus Statin ‘optimal’ for mixed dyslipidemia: Eur J Clin Nutr. 2010: Advance Online Publication
3. Red yeast rice and fish oil rival simvastatin for lipid-lowering ability: Mayo Clin Proc 2008; 83: 758-764
4. Effective use of combination lipid therapy: Curr Atheroscler Rep. 2006 Jan;8(1):76-84.
5. Long-term up to 24-month efficacy and safety of concomitant prescription omega-3-acid ethyl esters and simvastatin in hypertriglyceridemic patients: Curr Med Res Opin. 2010 Apr;26(4):907-15.
6. Effects of prescription omega-3-acid ethyl esters on non–high-density lipoprotein cholesterol when coadministered with escalating doses of atorvastatin: Mayo Clin Proc. 2010 Feb;85(2):122-8.
7. New data on the clinical impact of exercise training, fish oils, and statins in heart failure: Phys Sportsmed. 2009 Jun;37(2):22-8.
8. It can’t be more compatible. Omega-3 fatty acids in addition to statin provide optimal lipid management: MMW Fortschr Med. 2009 Nov 12;151(46):49.
9. Beyond blood lipids: phytosterols, statins and omega-3 polyunsaturated fatty acid therapy for hyperlipidemia: J Nutr Biochem. 2009 Dec;20(12):927-39. Epub 2009 Sep 3.
10. Omega 3 fatty acids induce a marked reduction of apolipoprotein B48 when added to fluvastatin in patients with type 2 diabetes and mixed hyperlipidemia: a preliminary report: Cardiovasc Diabetol. 2009 Jan 8;8:1.

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